Akti-1/2 | Tocris Bioscience 5773 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Akti-1/2

catalog :

5773

quantity :

10 mg (also 50 mg)

price :

173 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Kodaka M, Mao F, Arimoto Matsuzaki K, Kitamura M, Xu X, Yang Z, et al. Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells. PLoS ONE. 2020;15:e0231265 pubmed publisher
Zhong F, Chen Z, Zhang L, Xie Y, Nair V, Ju W, et al. Tyro3 is a podocyte protective factor in glomerular disease. JCI Insight. 2018;3: pubmed publisher
Perkins D, Richard K, Hansen A, Lai W, Nallar S, Koller B, et al. Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling. Nat Immunol. 2018;19:1309-1318 pubmed publisher

product information

brand :

Tocris

master code :

5773

SKU :

5773/10

product name :

Akti-1/2

description :

Potent and selective dual Akt1 and 2 inhibitor

target :

Akt (Protein Kinase B) Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

551.64

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective dual Akt1 and 2 inhibitor (IC50 values are 50 and 210 nM, respectively). Selective for Akt1 and 2 over a panel of other tyrosine and serine/threonine kinases. Sensitizes LnCaP cells to TRAIL (TNF-related apoptosis-inducing ligand) induced apoptosis. Also enhances CAR and TCR retroviral transduction of human T cells. Active in vivo .

catalog number base :

5773

product keywords :

Akt1/2 inhibitors inhibits potent selective PKB protein kinase B sensitizes apoptosis viral transduction enhancer enhances Akt Inhibitor VIII Akt (Protein Kinase B) Protein Kinase B/Akt Viral Transduction Enhancers 5773,

extended description :

Potent and selective dual Akt1 and 2 inhibitor

chemical name text :

1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one

formula :

C 34 H 29 N 7 O

formula text :

C34H29N7O

cas num :

612847-09-3

2020 USD :

166

2021 USD :

173 USD

alt names :

Akt Inhibitor VIII

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage