MONNA | Tocris Bioscience 5770/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MONNA

catalog :

5770/10

quantity :

10 mg (also 50 mg)

price :

185 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Dwivedi R, Drumm B, Alkawadri T, Martin S, Sergeant G, Hollywood M, et al. The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells. Eur J Pharmacol. 2023;947:175677 pubmed publisher

product information

brand :

Tocris

master code :

5770

SKU :

5770/10

rank :

0.0006

product name :

MONNA

description :

Potent TMEM16A (Anoctamin-1) blocker

target :

Calcium-activated Chloride Channel Blockers

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM). Exhibits 100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions. Carbachol (Cat. No. 2810) induced contraction of bronchial myocytes is reduced by MONNA and intracellular calcium release is increased.

extended description :

Potent TMEM16A (Anoctamin-1) blocker

chemical name text :

2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid

formula :

C 18 H 14 N 2 O 5

formula text :

C18H14N2O5

cas num :

1572936-83-4

USD :

185 USD

product details :

Potent TMEM16A (Anoctamin-1) blocker

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage