A 971432 | Tocris Bioscience 5766 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 971432

catalog :

5766

quantity :

10 mg (also 50 mg)

price :

149 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Matsushima Nishiwaki R, Yamada N, Fukuchi K, Kozawa O. Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2. PLoS ONE. 2018;13:e0209050 pubmed publisher

product information

brand :

Tocris

master code :

5766

SKU :

5766/10

product name :

A 971432

description :

Potent and selective S1P5 agonist

target :

Sphingosine-1-phosphate Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

366.24

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective S1P5 agonist (EC50 values are 4.1 and 5.7 nM in cAMP and GTP S assays, respectively). Exhibits 60-fold selectivity over S1P1, and 1,600-fold selectivity over S1P2-4, and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo . Orally available.

catalog number base :

5766

product keywords :

A971432 potent selective S1P5 sphingosine phosphate receptors neurodegeneration orally bioavailable blood-brain barrier Sphingosine-1-phosphate Receptors 5766,

extended description :

Potent and selective S1P5 agonist

chemical name text :

1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid

formula :

C 18 H 17 Cl 2 NO 3

formula text :

C18H17Cl2NO3

cas num :

1240308-45-5

2020 USD :

144

2021 USD :

149 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage