chemical

Tariquidar dihydrochloride

5757/10

10 mg (also 50 mg)

241 USD

5757

5757/10

0.0006

Tariquidar dihydrochloride

Potent P-glycoprotein (P-gp) inhibitor

Multidrug Transporter Inhibitors

Small Molecules

10 mg (also 50 mg)

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Tariquidar dihydrochloride is a potent P-glycoprotein (P-gp) inhibitor (IC50 = 5.1 nM). Reverses drug resistance in multiple MDR cell lines. Acts as a substrate for breast cancer resistance protein (BCRP) at low concentrations and acts as an inhibitor of BCRP when used at 100 nM concentration. Potentiates the cytotoxic effects of doxorubicin (Cat. No. 2252) and mitoxantrone (Cat. No. 4250) in vitro .

Potent P-glycoprotein (P-gp) inhibitor

N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarbxamide dihydrochloride

C 38 H 38 N 4 O 6 .2HCl

C38H38N4O6.2HCl

1992047-62-7

241 USD

Potent P-glycoprotein (P-gp) inhibitor

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.