PF 543 hydrochloride | Tocris Bioscience 5754 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 543 hydrochloride

catalog :

5754

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5754

SKU :

5754/10

product name :

PF 543 hydrochloride

description :

Potent and selective SphK1 inhibitor

target :

Sphingosine Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

502.07

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective SphK1 inhibitor (IC50 = 2 nM; Ki = 3.6 nM). Exhibits 100-fold selectivity for Sphk1 over Sphk2. Also exhibits 5,000 fold selectivity over S1P1-5 receptors and 48 protein and lipid kinases. Attenuates proliferation and induces necrosis in human colorectal cancer cells in vitro . Suppresses HCT-116 tumor xenograft growth in mice. Also reduces sickling, hemolysis and inflammation in a transgenic mouse model of sickle cell disease.

catalog number base :

5754

product keywords :

PF543 hydrochloride potent selective sphingosine kinases Sphk1 inhibitors inhibits Sphingosine Kinase 5754,

extended description :

Potent and selective SphK1 inhibitor

chemical name text :

(2R)-1-[[(4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol hydrochloride

formula :

C 27 H 31 NO 4 S.HCl

formula text :

C27H31NO4S.HCl

cas num :

1706522-79-3

2020 USD :

207

2021 USD :

216 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage