Apcin | Tocris Bioscience 5747 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Apcin

catalog :

5747

quantity :

10 mg (also 50 mg)

price :

171 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Afonso O, Castellani C, Cheeseman L, Ferreira J, Orr B, Ferreira L, et al. Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk. elife. 2019;8: pubmed publisher
Sackton K, Dimova N, Zeng X, Tian W, Zhang M, Sackton T, et al. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature. 2014;514:646-9 pubmed publisher

product information

brand :

Tocris

master code :

5747

SKU :

5747/10

product name :

Apcin

description :

Cdc20 inhibitor; inhibits Cdc20-substrate interaction

target :

Ubiquitin Ligase (E3) Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

438.65

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro .

catalog number base :

5747

product keywords :

Cdc20 inhibitors inhibits APC anaphase-promoting complex ubiquitin ubiquitination ligases E3 Ubiquitin E3 Ligases Mitosis 5747, E3 Ligase

extended description :

Cdc20 inhibitor; inhibits Cdc20-substrate interaction

chemical name text :

3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide

formula :

C 13 H 14 Cl 3 N 7 O 4

formula text :

C13H14Cl3N7O4

cas num :

300815-04-7

2020 USD :

164

2021 USD :

171 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage