Apcin | Tocris Bioscience 5747/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Apcin

catalog :

5747/10

quantity :

10 mg (also 50 mg)

price :

216 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Yin L, Mihajlovi x107 A, Yang G, FitzHarris G. Kinetochore deterioration concommitant with centromere weakening during aging in mouse oocyte meiosis-I. FASEB J. 2023;37:e22922 pubmed publisher
Asteriti I, Polverino F, Stagni V, Sterbini V, Ascanelli C, Naso F, et al. AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation. Life Sci Alliance. 2023;6: pubmed publisher
Holder J, Mohammed S, Barr F. Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit. elife. 2020;9: pubmed publisher
Paim L, FitzHarris G. Tetraploidy causes chromosomal instability in acentriolar mouse embryos. Nat Commun. 2019;10:4834 pubmed publisher
Afonso O, Castellani C, Cheeseman L, Ferreira J, Orr B, Ferreira L, et al. Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk. elife. 2019;8: pubmed publisher
De K, Grubb T, Zalenski A, Pfaff K, Pal D, Majumder S, et al. Hyperphosphorylation of CDH1 in Glioblastoma Cancer Stem Cells Attenuates APC/CCDH1 Activity and Pharmacologic Inhibition of APC/CCDH1/CDC20 Compromises Viability. Mol Cancer Res. 2019;: pubmed publisher
Sackton K, Dimova N, Zeng X, Tian W, Zhang M, Sackton T, et al. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature. 2014;514:646-9 pubmed publisher

image

image 1 :

Cat.No. 5747 - Apcin C13H14Cl3N7O4 CAS No. 300815-04-7

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5747

SKU :

5747/10

product name :

Apcin

description :

Cdc20 inhibitor; inhibits Cdc20-substrate interaction

target :

Ubiquitin Ligase (E3) Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

438.65

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Apcin is a Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro .

product keywords :

Cdc20 inhibitors inhibits APC anaphase-promoting complex ubiquitin ubiquitination ligases E3 Ubiquitin E3 Ligases Mitosis 5747, E3 Ligase

extended description :

Cdc20 inhibitor; inhibits Cdc20-substrate interaction

chemical name text :

3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide

formula :

C13H14Cl3N7O4

formula text :

C13H14Cl3N7O4

cas num :

300815-04-7

USD :

213

USD 2025 :

216 USD

product details :

Cdc20 inhibitor; inhibits Cdc20-substrate interaction

more info or order :

Tocris Bioscience product webpage