(+/-)-ADX 71743 | Tocris Bioscience 5715/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(+/-)-ADX 71743

catalog :

5715/10

quantity :

10 mg (also 50 mg)

price :

212 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Bodz x119 ta A, Berger F, MacGillavry H. Subsynaptic mobility of presynaptic mGluR types is differentially regulated by intra- and extracellular interactions. Mol Biol Cell. 2022;33:ar66 pubmed publisher

image

image 1 :

Cat.No. 5715 - (?)-ADX 71743 C17H19NO2

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5715

SKU :

5715/10

product name :

(+/-)-ADX 71743

description :

Negative allosteric modulator of mGlu7 receptors; brain penetrant

target :

Group III mGluR Modulators

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

269.34

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

( )-ADX 71743 is a negative allosteric modulator at mGlu7 (IC50 = 300 nM). Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro . Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.

product keywords :

(?)-ADX 71743 potent negative allosteric modulators NAMs mGlu7 receptors metabotropic glutamate epilepsy 1431641-29-0 Glutamate (Metabotropic) Group III Receptors 5715,

extended description :

Negative allosteric modulator of mGlu7 receptors; brain penetrant

chemical name text :

6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone

formula :

C17H19NO2

formula text :

C17H19NO2

USD :

235

USD 2025 :

212 USD

product details :

Negative allosteric modulator of mGlu7 receptors; brain penetrant

more info or order :

Tocris Bioscience product webpage