MS 023 dihydrochloride | Tocris Bioscience 5713/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MS 023 dihydrochloride

catalog :

5713/10

quantity :

10 mg

price :

303 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Tang S, Sethunath V, Metaferia N, Nogueira M, Gallant D, Garner E, et al. A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer. Cell Rep. 2022;38:110417 pubmed publisher
Lu S, De Neef E, Thomas J, SABIO E, Rousseau B, Gigoux M, et al. Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell. 2021;184:4032-4047.e31 pubmed publisher
Choucair A, Pham T, Omarjee S, Jacquemetton J, Kassem L, Tredan O, et al. The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer. Oncogene. 2019;38:4015-4027 pubmed publisher

image

image 1 :

Cat.No. 5713 - MS 023 dihydrochloride C17H25N3O.2HCl CAS No. 1992047-64-9

product information

brand :

Tocris

catalog number base :

5713

SKU :

5713/10

product name :

MS 023 dihydrochloride

units size :

10 mg

description :

Potent and selective type I PRMT inhibitor

target :

Protein Arginine Methyltransferase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

360.32

url print :

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details of functionality :

MS 023 dihydrochloride is a potent and selective type I PRMT inhibitor (IC50 values are 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively). Exhibits no significant activity against type II and III PRMTs, PKMTs, DNMTs, KDMs and reader proteins. Reduces global arginine asymmetric dimethylation levels in vitro . Also inhibits and reduces TGF- -activated kinase 1 expression and protein levels.

top caption :

Potent and selective type I PRMT inhibitor

extended description :

Potent and selective type I PRMT inhibitor

chemical name text :

N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride

formula :

C17H25N3O.2HCl

formula text :

C17H25N3O.2HCl

cas num :

1992047-64-9

USD :

303 USD

product details :

Potent and selective type I PRMT inhibitor

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage