M62812 | Tocris Bioscience 5705 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

M62812

catalog :

5705

quantity :

10 mg (also 50 mg)

price :

123 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Nakamura M, Shimizu Y, Sato Y, Miyazaki Y, Satoh T, Mizuno M, et al. Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur J Pharmacol. 2007;569:237-43 pubmed

product information

brand :

Tocris

master code :

5705

SKU :

5705/10

product name :

M62812

description :

TLR-4 inhibitor

target :

Toll-like Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

330.23

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TLR4 inhibitor. Inhibits LPS-induced NF- B activation in HEK293 cells (IC50 = 2.4 g/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.

catalog number base :

5705

product keywords :

Toll-like receptors inhibits inhibitors TLR-4 sepsis septic shock Toll-like Receptors 5705,

extended description :

TLR-4 inhibitor

chemical name text :

6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine dihydrochloride

formula :

C 13 H 11 N 3 OS.2HCl

formula text :

C13H11N3OS.2HCl

cas num :

613263-00-6

2020 USD :

119

2021 USD :

123 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage