product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
AMG 853
catalog :
5701
quantity :
10 mg
price :
320 USD
more info or order :
Tocris Bioscience product webpage
product information
brand :
Tocris
master code :
5701
SKU :
5701/10
product name :
AMG 853
description :
Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist
target :
Prostanoid Receptor Antagonists
category :
Small Molecules
unit size :
10 mg
purity :
98%
observed molecular weight :
609.49
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent prostaglandin D2 (PGD2, CRTH2) receptor antagonist (IC50 values are 8 and 35 nM, respectively in plasma). Inhibits PGD2-induced down modulation of CRTH2 on CD16- granulocytes in human whole blood as well as PGD2-induced cAMP response in platelets. Inhibits PGD2-induced airway constriction in vivo . Orally bioavailable.
catalog number base :
5701
product keywords :
AMG853 CRTH2 chemoattractant receptor-homologous molecule expressed on Th2 cells PGD2 prostaglandin receptor dual antagonists antagonism orally DP2 bioavailable Prostanoid Receptors 5701,
extended description :
Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist
chemical name text :
5-Chloro-4-[2-[[(2-chloro-4-cyclopropylphenyl)sulfonyl]amino]-4-[[(1,1-dimethylethyl)amino]carbonyl]phenoxy]-2-fluorobenzeneacetic acid
formula :
C 28 H 27 Cl 2 FN 2 O 6 S
formula text :
C28H27Cl2FN2O6S
cas num :
1169483-24-2
2020 USD :
307
2021 USD :
320 USD
storage :
Store at -20°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK