Eggmanone | Tocris Bioscience 5695 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Eggmanone

catalog :

5695

quantity :

10 mg (also 50 mg)

price :

147 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Kan C, Chen L, Hu Y, Ding N, Li Y, McGuire T, et al. Gli1-labeled adult mesenchymal stem/progenitor cells and hedgehog signaling contribute to endochondral heterotopic ossification. Bone. 2018;109:71-79 pubmed publisher

product information

brand :

Tocris

master code :

5695

SKU :

5695/10

product name :

Eggmanone

description :

Potent and selective PDE4 inhibitor; suppresses hedgehog signaling

target :

Phosphodiesterase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

416.58

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 = 72 nM). Exhibits 40-fold selectivity over PDE3, PDE10, and PDE11. Displays no significant activity on a panel of 442 kinases, 158 GPCRs and 21 phosphatases. Suppresses hedgehog signaling through PDE antagonism, downstream of smoothened signaling. Reduces transcription of Gli1 and Ptc1 .

catalog number base :

5695

product keywords :

Potent selective phosphodiesterases PDE 4 inhibitors inhibits hedgehog signallling Phosphodiesterases Hedgehog Signaling 5695,

extended description :

Potent and selective PDE4 inhibitor; suppresses hedgehog signaling

chemical name text :

5,6,7,8-Tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-[1]benzothieno[2,3-d]pyrimidin-4(3H)-one

formula :

C 20 H 20 N 2 O 2 S 3

formula text :

C20H20N2O2S3

cas num :

505068-32-6

2020 USD :

163

2021 USD :

147 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage