Centrinone B | Tocris Bioscience 5690 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Centrinone B

catalog :

5690

quantity :

10 mg

price :

259 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Mues M, Karra L, Romero Moya D, Wandler A, Hangauer M, Ksionda O, et al. High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions. Cell Rep. 2019;27:631-647.e5 pubmed publisher
Chen H, Wu C, Tang C, Lin Y, Wang W, Tang T. Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles. Nat Commun. 2017;8:247 pubmed publisher
Kazazian K, Go C, Wu H, Brashavitskaya O, Xu R, Dennis J, et al. Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton. Cancer Res. 2017;77:434-447 pubmed publisher

product information

brand :

Tocris

master code :

5690

SKU :

5690/10

product name :

Centrinone B

description :

High affinity and selective PLK4 inhibitor

target :

Polo-like Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

631.67

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity and selective PLK4 inhibitor (Ki = 0.6 nM). Exhibits 2000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro . Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.

catalog number base :

5690

product keywords :

LCR323 high affinity selective PLK4 inhibitors inhibits centriole centrosome LCR 323 Polo-like Kinase Mitosis 5690,

extended description :

High affinity and selective PLK4 inhibitor

chemical name text :

2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine

formula :

C 27 H 27 F 2 N 7 O 5 S 2

formula text :

C27H27F2N7O5S2

cas num :

1798871-31-4

2020 USD :

249

2021 USD :

259 USD

alt names :

LCR 323

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage