Centrinone B | Tocris Bioscience 5690/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Centrinone B

catalog :

5690/10

quantity :

10 mg

price :

327 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Ng D, Ali A, Lee K, Eymael D, Abe K, Luu S, et al. Investigating the mechanisms of peritoneal metastasis in gastric adenocarcinoma using a novel ex vivo peritoneal explant model. Sci Rep. 2022;12:11499 pubmed publisher
T xe1 trai P, Gergely F. Centrosome function is critical during terminal erythroid differentiation. EMBO J. 2022;41:e108739 pubmed publisher
Klemm L, Denu R, Hind L, Rocha Gregg B, Burkard M, Huttenlocher A. Centriole and Golgi microtubule nucleation are dispensable for the migration of human neutrophil-like cells. Mol Biol Cell. 2021;32:1545-1556 pubmed publisher
Kazazian K, Haffani Y, Ng D, Lee C, Johnston W, Kim M, et al. FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity. Commun Biol. 2020;3:448 pubmed publisher
Kong D, Sahabandu N, Sullenberger C, Vásquez Limeta A, Luvsanjav D, Lukasik K, et al. Prolonged mitosis results in structurally aberrant and over-elongated centrioles. J Cell Biol. 2020;219: pubmed publisher
Mues M, Karra L, Romero Moya D, Wandler A, Hangauer M, Ksionda O, et al. High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions. Cell Rep. 2019;27:631-647.e5 pubmed publisher
Chen H, Wu C, Tang C, Lin Y, Wang W, Tang T. Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles. Nat Commun. 2017;8:247 pubmed publisher
Kazazian K, Go C, Wu H, Brashavitskaya O, Xu R, Dennis J, et al. Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton. Cancer Res. 2017;77:434-447 pubmed publisher

image

image 1 :

Cat.No. 5690 - Centrinone B C27H27F2N7O5S2 CAS No. 1798871-31-4

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5690

SKU :

5690/10

product name :

Centrinone B

description :

High affinity and selective PLK4 inhibitor

target :

Polo-like Kinase Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

631.67

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Centrinone B is a high affinity and selective PLK4 inhibitor (Ki = 0.6 nM). Exhibits 2000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro . Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.

product keywords :

LCR323 high affinity selective PLK4 inhibitors inhibits centriole centrosome LCR 323 Polo-like Kinase Mitosis 5690,

extended description :

High affinity and selective PLK4 inhibitor

chemical name text :

2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine

formula :

C27H27F2N7O5S2

formula text :

C27H27F2N7O5S2

cas num :

1798871-31-4

USD :

323

USD 2025 :

327 USD

product details :

High affinity and selective PLK4 inhibitor

alt names :

LCR 323

more info or order :

Tocris Bioscience product webpage