product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Centrinone
catalog :
5687
quantity :
10 mg
price :
259 USD
more info or order :
Tocris Bioscience product webpage
product information
brand :
Tocris
master code :
5687
SKU :
5687/10
product name :
Centrinone
description :
High affinity and selective PLK4 inhibitor
target :
Polo-like Kinase Inhibitors
category :
Small Molecules
unit size :
10 mg
purity :
98%
observed molecular weight :
633.65
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
High affinity and selective PLK4 inhibitor (Ki = 0.16 nM). Exhibits 1000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro . Induces cell cycle arrest in normal human cell lines in a p53-dependent manner. Decreases expression of pluripotency markers and induces differentiation in pluripotent stem cells.
catalog number base :
5687
product keywords :
High affinity selective PLK4 inhibitors inhibits centriole centrosome Polo-like Kinase Mitosis ESCs and iPSC 5687,
extended description :
High affinity and selective PLK4 inhibitor
chemical name text :
2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-4-pyrimidinamine
formula :
C 26 H 25 F 2 N 7 O 6 S 2
formula text :
C26H25F2N7O6S2
cas num :
1798871-30-3
2020 USD :
249
2021 USD :
259 USD
storage :
Store at -20°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK