MMAE | Tocris Bioscience 5683 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MMAE

catalog :

5683

quantity :

1 mg

price :

149 USD

product information

brand :

Tocris

master code :

5683

SKU :

5683/1

product name :

MMAE

description :

Potent dolastatin 10 analog; antitumor

target :

Microtubule Binding Compounds

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

717.98

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, synthetic, cytotoxic analog of dolastatin 10 (Cat. No. 3375). Suppresses tumor cell viability in vitro (GIC50 values are 0.22, 0.49 and 0.54 nM in BT474, MDA-MB-361-DYT2 and N87 cells, respectively). MMAE derivatives have been shown to induce regression of established tumor xenografts when conjugated to tumor targeting antibodies via a protease-cleavable linker.

catalog number base :

5683

product keywords :

monomethylauristatin E Potent cytotoxic dolastatin 10 analogues anticancer antitumour antitumor tubulin polymerization agents Microtubules Mitosis 5683,

extended description :

Potent dolastatin 10 analog; antitumor

chemical name text :

N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide

formula :

C 39 H 67 N 5 O 7

formula text :

C39H67N5O7

cas num :

474645-27-7

2020 USD :

144

2021 USD :

149 USD

storage :

Store at -20°C