GW 2580 | Tocris Bioscience 5673/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GW 2580

catalog :

5673/10

quantity :

10 mg (also 50 mg)

price :

189 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Moon H, Kim S, Jeong J, Han S, Jarjour N, Lee H, et al. Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization. Immunity. 2018;49:275-287.e5 pubmed publisher

image

image 1 :

Cat.No. 5673 - GW 2580 C20H22N4O3 CAS No. 870483-87-7

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5673

SKU :

5673/10

product name :

GW 2580

description :

Selective cFMS kinase inhibitor; orally bioavailable

target :

Additional RTK Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at -20°C

observed molecular weight :

366.41

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GW 2580 is a potent and selective cFMS kinase inhibitor (IC50 = 0.06 M). Exhibits selectivity for cFMS kinase over 186 other kinases. Inhibits CSF-1-induced growth of rat monocytes in vitro . Also inhibits bone resorption in osteoclast cultures, as well as connective tissue and bone destruction in a rat adjuvant arthritis model. Suppresses M-NFS-60 tumor cell growth in mice. Orally bioavailable.

product keywords :

GW2580 cFMS kinase inhibitors inhibits CSF-1 colony-stimulating factor osteoclasts arthritis selective orally bioavailable Other RTKs 5673,

extended description :

Selective cFMS kinase inhibitor; orally bioavailable

chemical name text :

5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine

formula :

C20H22N4O3

formula text :

C20H22N4O3

cas num :

870483-87-7

USD :

187

USD 2025 :

189 USD

product details :

Selective cFMS kinase inhibitor; orally bioavailable

more info or order :

Tocris Bioscience product webpage