666-15 | Tocris Bioscience 5661 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

666-15

catalog :

5661

quantity :

10 mg (also 50 mg)

price :

262 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Zhou L, Peng J, Xu Y, Zeng W, Zhang J, Wei X, et al. Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain. Cell Rep. 2019;27:3844-3859.e6 pubmed publisher
Hamnett R, Crosby P, Chesham J, Hastings M. Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling. Nat Commun. 2019;10:542 pubmed publisher
O Reilly M, Kajani S, Ralston J, Lenighan Y, Roche H, McGillicuddy F. Nutritionally Derived Metabolic Cues Typical of the Obese Microenvironment Increase Cholesterol Efflux Capacity of Adipose Tissue Macrophages. Mol Nutr Food Res. 2019;63:e1800713 pubmed publisher
Kleiner J, Hollborn M, Wiedemann P, Bringmann A. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis. 2018;24:647-666 pubmed
Phua T, Sng M, Tan E, Chee D, Li Y, Wee J, et al. Angiopoietin-like 4 Mediates Colonic Inflammation by Regulating Chemokine Transcript Stability via Tristetraprolin. Sci Rep. 2017;7:44351 pubmed publisher

product information

brand :

Tocris

master code :

5661

SKU :

5661/10

product name :

666-15

description :

Potent and selective CREB inhibitor

target :

Additional Transcription Factor Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

620.52

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective CREB inhibitor (IC50 = 81 nM). Inhibits cancer cell growth, without harming normal cells (up to 1 M). Completely suppresses tumor growth in a breast cancer xenograft model.

catalog number base :

5661

product keywords :

cyclic adenosine monophosphate cAMP response element binding protein CREB inhibitors inhibits breast cancer potent selective Other Transcription Factors 5661,

extended description :

Potent and selective CREB inhibitor

chemical name text :

3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride

formula :

C 33 H 30 ClN 3 O 5 .HCl

formula text :

C33H30ClN3O5.HCl

cas num :

1433286-70-4

2020 USD :

249

2021 USD :

262 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage