666-15 | Tocris Bioscience 5661/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

666-15

catalog :

5661/10

quantity :

10 mg (also 50 mg)

price :

304 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Zhou L, Peng J, Xu Y, Zeng W, Zhang J, Wei X, et al. Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain. Cell Rep. 2019;27:3844-3859.e6 pubmed publisher
Hamnett R, Crosby P, Chesham J, Hastings M. Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling. Nat Commun. 2019;10:542 pubmed publisher
O Reilly M, Kajani S, Ralston J, Lenighan Y, Roche H, McGillicuddy F. Nutritionally Derived Metabolic Cues Typical of the Obese Microenvironment Increase Cholesterol Efflux Capacity of Adipose Tissue Macrophages. Mol Nutr Food Res. 2019;63:e1800713 pubmed publisher
Kleiner J, Hollborn M, Wiedemann P, Bringmann A. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells. Mol Vis. 2018;24:647-666 pubmed
Phua T, Sng M, Tan E, Chee D, Li Y, Wee J, et al. Angiopoietin-like 4 Mediates Colonic Inflammation by Regulating Chemokine Transcript Stability via Tristetraprolin. Sci Rep. 2017;7:44351 pubmed publisher

product information

brand :

Tocris

master code :

5661

SKU :

5661/10

rank :

0.061

product name :

666-15

description :

Potent and selective CREB inhibitor

target :

Additional Transcription Factor Compounds

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

666-15 is a potent and selective CREB inhibitor (IC50 = 81 nM). Inhibits cancer cell growth, without harming normal cells (up to 1 M). Completely suppresses tumor growth in a breast cancer xenograft model.

extended description :

Potent and selective CREB inhibitor

chemical name text :

3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride

formula :

C 33 H 30 ClN 3 O 5 .HCl

formula text :

C33H30ClN3O5.HCl

cas num :

1433286-70-4

USD :

304 USD

product details :

Potent and selective CREB inhibitor

storage :

Store the unopened product at room temperature. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage