JW 74 | Tocris Bioscience 5653 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JW 74

catalog :

5653

quantity :

10 mg (also 50 mg)

price :

157 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Rothberg J, Maganti H, Jrade H, Porter C, Palidwor G, Cafariello C, et al. Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis. Cell Discov. 2018;4:21 pubmed publisher

product information

brand :

Tocris

master code :

5653

SKU :

5653/10

product name :

JW 74

description :

Wnt pathway inhibitor

target :

Other Wnt Signaling Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

456.52

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of canonical Wnt signaling (IC50 = 790 nM). Targets the -catenin destruction complex (GSK-3?/AXIN/APC). Increases AXIN2 and decreases active -catenin levels in colorectal cancer (CRC) cells. Also arrests cell cycle in G1 and inhibits proliferation of CRC cells in vitro . Inhibits tumor growth and formation in mouse models.

catalog number base :

5653

product keywords :

JW74 canonical Wnt signaling pathway inhibitors inhibits cancer -catenin AXIN2 Beta-catenin Other Wnt Signaling 5653,

extended description :

Wnt pathway inhibitor

chemical name text :

4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine

formula :

C 24 H 20 N 6 O 2 S

formula text :

C24H20N6O2S

cas num :

863405-60-1

2020 USD :

152

2021 USD :

157 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage