MSC 2032964A | Tocris Bioscience 5641/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MSC 2032964A

catalog :

5641/10

quantity :

10 mg (also 50 mg)

price :

278 USD

citations: 2

Reference
G xf3 mora Garc xed a J, Ger xf3 nimo Olvera C, P xe9 rez Mart xed nez X, Massieu L. IRE1α RIDD activity induced under ER stress drives neuronal death by the degradation of 14-3-3 θ mRNA in cortical neurons during glucose deprivation. Cell Death Discov. 2021;7:131 pubmed publisher
Park H, Shin D, Sim J, Aum S, Lee M. IRE1α kinase-mediated unconventional protein secretion rescues misfolded CFTR and pendrin. Sci Adv. 2020;6:eaax9914 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5641

SKU :

5641/10

product name :

MSC 2032964A

description :

Potent and selective ASK1 inhibitor; orally bioavailable

target :

ASK1 Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

97%

storage :

Store at -20°C

observed molecular weight :

362.31

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MSC 2032964A is a potent and selective ASK1 inhibitor (IC50 = 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and brain penetrant.

product keywords :

MSC2032964A apoptosis signal regulating kinase 1 ASK1 inhibits inhibitors potent selective orally bioavailable neuroinflammation EAE experimental autoimmune encephalomyelitis ASK1 5641,

extended description :

Potent and selective ASK1 inhibitor; orally bioavailable

chemical name text :

N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide

formula :

C16H13F3N6O

formula text :

C16H13F3N6O

cas num :

1124381-43-6

USD :

275

USD 2025 :

278 USD

product details :

Potent and selective ASK1 inhibitor; orally bioavailable