AZD 1480 | Tocris Bioscience 5617/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZD 1480

catalog :

5617/10

quantity :

10 mg

price :

335 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Nowery J, Cisney R, Feldmann J, Meares G. Nitric Oxide Induces a Janus Kinase-1-Dependent Inflammatory Response in Primary Murine Astrocytes. ASN Neuro. 2021;13:17590914211033650 pubmed publisher
Brouwer I, Out Luiting J, Vermeer M, Tensen C. Cucurbitacin E and I target the JAK/STAT pathway and induce apoptosis in Sézary cells. Biochem Biophys Rep. 2020;24:100832 pubmed publisher

image

image 1 :

Cat.No. 5617 - AZD 1480 C14H14ClFN8 CAS No. 935666-88-9

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5617

SKU :

5617/10

product name :

AZD 1480

description :

Potent and selective JAK2 inhibitor; antiangiogenic

target :

JAK Kinase Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

348.77

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AZD 1480 is a potent and selective JAK2 inhibitor (IC50 3 nM). Exhibits 50-fold selectivity for JAK2 over JAK3. Exhibits antitumor effects and inhibits formation of lung metastases in a mouse renal cancer model. Also inhibits STAT3 signaling, tumor angiogenesis and myeloid cell migration in vivo .

product keywords :

AZD1480 JAK2 inhibitors cancer anticancers metastasis angiogenesis STAT3 signaling potent selective inhibits JAK Antiangiogenics JAK Kinase 5617,

extended description :

Potent and selective JAK2 inhibitor; antiangiogenic

chemical name text :

5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidine-2,4-diamine

formula :

C14H14ClFN8

formula text :

C14H14ClFN8

cas num :

935666-88-9

USD :

331

USD 2025 :

335 USD

product details :

Potent and selective JAK2 inhibitor; antiangiogenic

more info or order :

Tocris Bioscience product webpage