chemical

GNF 7

5607/10

10 mg (also 50 mg)

193 USD

5607

5607/10

GNF 7

Ras signaling inhibitor; inhibits Ack1 and GCK

Ras GTPase Inhibitors

10 mg (also 50 mg)

Small Molecules

98%

Store at -20°C

547.53

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GNF 7 is a potent Bcr-Abl inhibitor (IC50 values are 61 and 133 nM for T315I and wild-type Bcr-Abl, respectively), inhibiting a range of clinically relevant Bcr-Abl mutants such as T315I, G250E, E255V, F317L and M351T. GNF 7 is also a Ras signaling inhibitor as well as inhibiting Ack1 and germinal center kinase (GCK). GNF 7 induces cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations, and shows growth inhibitory activity in human colon cancer cells. It prolongs survival in a leukemia cell xenotransplantation model in mice and is orally bioavailable.

GNF7 RAS inhibitors inhibits Ack1 germinal centre kinases GCK leukemia TNK2 Bcr-Abl GNF-7 Ack1 Ras GTPases Abl Kinase 5607, Ras, GTP ase

Ras signaling inhibitor; inhibits Ack1 and GCK

N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide

C28H24F3N7O2

C28H24F3N7O2

839706-07-9

214

193 USD

Ras signaling inhibitor; inhibits Ack1 and GCK