A66 | Tocris Bioscience 5595/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A66

catalog :

5595/10

quantity :

10 mg (also 50 mg)

price :

211 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Zhang B, Luk C, Valadares J, Aronis C, Foukas L. Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling. Int J Mol Sci. 2021;22: pubmed publisher
Mannella V, Boehm K, Celik S, Ali T, Mirza A, El Hasnaouy M, et al. Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors. Int J Mol Sci. 2021;22: pubmed publisher
Bettedi L, Yan A, Schuster E, Alic N, Foukas L. Increased mitochondrial and lipid metabolism is a conserved effect of Insulin/PI3K pathway downregulation in adipose tissue. Sci Rep. 2020;10:3418 pubmed publisher
Jin Y, Valenzuela N, Zhang X, Rozengurt E, Reed E. HLA Class II-Triggered Signaling Cascades Cause Endothelial Cell Proliferation and Migration: Relevance to Antibody-Mediated Transplant Rejection. J Immunol. 2018;200:2372-2390 pubmed publisher
Hao F, Xu Q, Zhao Y, Stevens J, Young S, Sinnett Smith J, et al. Insulin Receptor and GPCR Crosstalk Stimulates YAP via PI3K and PKD in Pancreatic Cancer Cells. Mol Cancer Res. 2017;15:929-941 pubmed publisher

image

image 1 :

Cat.No. 5595 - A66 C17H23N5O2S2 CAS No. 1166227-08-2

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5595

SKU :

5595/10

product name :

A66

description :

Potent and selective PI 3-kinase p110 inhibitor

target :

PI 3-Kinase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

393.53

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A66 is a potent and selective PI 3-kinase p110 inhibitor (IC50 = 32 nM). Exhibits 100-fold selectivity for p110 over other PI 3-kinase isoforms. Inhibits Akt signaling and tumor growth in SK-OV-3 xenografts in mice.

product keywords :

PI 3-kinase PI3K phosphoinositide 3-kinase inhibitors potent selective inhibits p110a alpha PI 3-Kinase 5595,

extended description :

Potent and selective PI 3-kinase p110 inhibitor

chemical name text :

(2S)-N1-[2-(1,1-Dimethylethyl)-4 -methyl[4,5 -bithiazol]-2 -yl]-1,2-pyrrolidinedicarboxamide

formula :

C17H23N5O2S2

formula text :

C17H23N5O2S2

cas num :

1166227-08-2

USD :

208

USD 2025 :

211 USD

product details :

Potent and selective PI 3-kinase p110 inhibitor

more info or order :

Tocris Bioscience product webpage