LCB 03-0110 dihydrochloride | Tocris Bioscience 5592/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LCB 03-0110 dihydrochloride

catalog :

5592/10

quantity :

10 mg (also 50 mg)

price :

281 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Fowler A, Hebron M, Balaraman K, Shi W, Missner A, Greenzaid J, et al. Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases. Hum Mol Genet. 2020;29:2882-2898 pubmed publisher
Fowler A, Hebron M, Missner A, Wang R, Gao X, Kurd Misto B, et al. Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration. Drugs R D. 2019;19:149-166 pubmed publisher
Mogami H, Kishore A, Word R. Collagen Type 1 Accelerates Healing of Ruptured Fetal Membranes. Sci Rep. 2018;8:696 pubmed publisher

image

image 1 :

Cat.No. 5592 - LCB 03-0110 dihydrochloride C24H23N3O2S.2HCl

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5592

SKU :

5592/10

product name :

LCB 03-0110 dihydrochloride

description :

Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

target :

Src Family Kinase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Desiccate at RT

observed molecular weight :

490.45

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

LCB 03-0110 dihydrochloride is a potent c-Src kinase inhibitor (IC50 = 1.3 nM). Also potent inhibitor of discoidin domain receptor 2 (DDR2) family tyrosine kinases, BTK and Syk. Suppresses LPS-induced activation of macrophages and TGF- 1- induced activation of fibroblasts in vitro . Also inhibits activation of macrophages and fibroblasts and suppresses scar formation in a wound healing model.

product keywords :

src kinase inhibitors inhibits potent discoidin domain receptor DDR wound healing Bruton's tyrosine BTK syk anti-inflammatory potent Src Kinases Brutons Tyrosine Kinase (BTK) Syk Kinase Other RTKs 5592,

extended description :

Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

chemical name text :

3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride

formula :

C24H23N3O2S.2HCl

formula text :

C24H23N3O2S.2HCl

cas num :

1962928-28-4

USD :

278

USD 2025 :

281 USD

product details :

Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

more info or order :

Tocris Bioscience product webpage