I-BRD9 | Tocris Bioscience 5591/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

I-BRD9

catalog :

5591/10

quantity :

10 mg (also 50 mg)

price :

240 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Du J, Liu Y, Wu X, Sun J, Shi J, Zhang H, et al. BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism. Nat Commun. 2023;14:1413 pubmed publisher
Ahmed N, Gatchalian J, Ho J, Burns M, Hah N, Wei Z, et al. BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher
Zhou Q, Huang J, Zhang C, Zhao F, Kim W, Tu X, et al. The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair. Nat Commun. 2020;11:2639 pubmed publisher
Brien G, Remillard D, Shi J, Hemming M, Chabon J, Wynne K, et al. Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. elife. 2018;7: pubmed publisher
Wei Z, Yoshihara E, He N, Hah N, Fan W, Pinto A, et al. Vitamin D Switches BAF Complexes to Protect β Cells. Cell. 2018;173:1135-1149.e15 pubmed publisher

image

image 1 :

Cat.No. 5591 - I-BRD9 C22H22F3N3O3S2 CAS No. 1714146-59-4

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5591

SKU :

5591/10

product name :

I-BRD9

description :

Potent and selective BRD9 inhibitor

target :

Bromodomain Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

497.55

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

I-BRD9 is a potent and selective BRD9 inhibitor (pIC50 = 7.3). Exhibits 70-fold selectivity for BRD9 over a panel of 34 other bromodomains and 700-fold selectivity over the BET family. Downregulates CLEC 1, DUSP6 , FES and SAMSN 1 genes in Kasumi-1 cells.

product keywords :

bromodomains containing protein extra terminal inhibits inhibitors potent selective downregulates downregulation sgc structural genomics consortium Bromodomains 5591,

extended description :

Potent and selective BRD9 inhibitor

chemical name text :

5-Ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide

formula :

C22H22F3N3O3S2

formula text :

C22H22F3N3O3S2

cas num :

1714146-59-4

USD :

266

USD 2025 :

240 USD

product details :

Potent and selective BRD9 inhibitor

more info or order :

Tocris Bioscience product webpage