Yoda 1 | Tocris Bioscience 5586 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Yoda 1

catalog :

5586

quantity :

10 mg (also 50 mg)

price :

152 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Chubinskiy Nadezhdin V, Vasileva V, Vassilieva I, Sudarikova A, Morachevskaya E, Negulyaev Y. Agonist-induced Piezo1 activation suppresses migration of transformed fibroblasts. Biochem Biophys Res Commun. 2019;514:173-179 pubmed publisher
Tsuchiya M, Hara Y, Okuda M, Itoh K, Nishioka R, Shiomi A, et al. Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation. Nat Commun. 2018;9:2049 pubmed publisher
Romac J, Shahid R, Swain S, Vigna S, Liddle R. Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis. Nat Commun. 2018;9:1715 pubmed publisher
dela Paz N, Frangos J. Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation. Biochem Biophys Res Commun. 2018;497:220-225 pubmed publisher
Ilkan Z, Wright J, Goodall A, Gibbins J, Jones C, Mahaut Smith M. Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line. J Biol Chem. 2017;292:9204-9217 pubmed publisher

product information

brand :

Tocris

master code :

5586

SKU :

5586/10

product name :

Yoda 1

description :

Piezo1 channel activator

target :

Piezo Channel Activators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

355.27

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Piezo1 channel activator. Slows the inactivation phase of transient currents, sensitizes Piezo1 to activation by pressure, and partially activates channels in the absence of external pressure, in HEK cells expressing Piezo1 channels.

catalog number base :

5586

product keywords :

Yoda1 Piezo1 calcium channels activators sensitizers sensitizes Ca2+ currents mechanotransduction Piezo Channels 5586,

extended description :

Piezo1 channel activator

chemical name text :

2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine

formula :

C 13 H 8 Cl 2 N 4 S 2

formula text :

C13H8Cl2N4S2

cas num :

448947-81-7

2020 USD :

146

2021 USD :

152 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage