Yoda 1 | Tocris Bioscience 5586/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Yoda 1

catalog :

5586/10

quantity :

10 mg (also 50 mg)

price :

177 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Chubinskiy Nadezhdin V, Vasileva V, Vassilieva I, Sudarikova A, Morachevskaya E, Negulyaev Y. Agonist-induced Piezo1 activation suppresses migration of transformed fibroblasts. Biochem Biophys Res Commun. 2019;514:173-179 pubmed publisher
Tsuchiya M, Hara Y, Okuda M, Itoh K, Nishioka R, Shiomi A, et al. Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation. Nat Commun. 2018;9:2049 pubmed publisher
Romac J, Shahid R, Swain S, Vigna S, Liddle R. Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis. Nat Commun. 2018;9:1715 pubmed publisher
dela Paz N, Frangos J. Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation. Biochem Biophys Res Commun. 2018;497:220-225 pubmed publisher
Ilkan Z, Wright J, Goodall A, Gibbins J, Jones C, Mahaut Smith M. Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line. J Biol Chem. 2017;292:9204-9217 pubmed publisher

product information

brand :

Tocris

master code :

5586

SKU :

5586/10

rank :

0.061

product name :

Yoda 1

description :

Piezo1 channel activator

target :

Piezo Channel Activators

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Yoda 1 is a selective activator of mouse and human mechanosensitive channel piezo1. In HEK cells, Yoda 1 slows the inactivation phase of transient currents, sensitizes Piezo1 to activation by pressure, and partially activates channels in the absence of external pressure. In MDCK cells, Yoda 1 induces Ca2+-dependent chromatin hypercondensation and alters Ca2+-dependent myosin contractility, leading to nuclear shrinkage in cells. In red blood cells from sickle cell anemia (SCA) patients, Yoda 1 increases intracellular Ca2+ and phosphatidylserine exposure, which leads to KCa3.1 channel mediated Ca2+ influx and K+ and water efflux, causing shrinkage of the cells.

extended description :

Piezo1 channel activator

chemical name text :

2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine

formula :

C 13 H 8 Cl 2 N 4 S 2

formula text :

C13H8Cl2N4S2

cas num :

448947-81-7

USD :

177 USD

product details :

Piezo1 channel activator

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage