5582/1 | Tocris Bioscience 5582/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5582/1

catalog :

5582/1

quantity :

1 mg

price :

330 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Zhan Q, Jeon J, Li Y, Huang Y, Xiong J, Wang Q, et al. CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux. Autophagy. 2021;:1-19 pubmed publisher
Miranda E, Nordgren I, Male A, Lawrence C, Hoakwie F, Cuda F, et al. A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J Am Chem Soc. 2013;135:10418-25 pubmed publisher

product information

master code :

5582

SKU :

5582/1

product name :

TAT-cyclo-CLLFVY

unit size :

1 mg

description :

Selective HIF-1 dimerization inhibitor

target :

HIF Inhibitors

category :

Peptides

purity :

95%

observed molecular weight :

2559.1

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1 , but not HIF-2 , with HIF-1 (IC50 = 1.3 M) . Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro . Also reduces tubularization of hypoxic HUVECs.

top caption :

Selective HIF-1 dimerization inhibitor

extended description :

Selective HIF-1 dimerization inhibitor

formula :

C111H188N42O24S2

formula text :

C111H188N42O24S2

cas num :

1446322-66-2

USD :

330 USD

product details :

Selective HIF-1 dimerization inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage