DMH2 | Tocris Bioscience 5580 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

DMH2

catalog :

5580

quantity :

10 mg (also 50 mg)

price :

212 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Stuart H, Stirparo G, Lohoff T, Bates L, Kinoshita M, Lim C, et al. Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell Stem Cell. 2019;25:388-406.e8 pubmed publisher

product information

brand :

Tocris

master code :

5580

SKU :

5580/10

product name :

DMH2

description :

Type I BMP receptor inhibitor

target :

BMP and Other Activin Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

451.52

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Type I BMP receptor inhibitor (Ki values are 1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits 30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro . Enhances liver regeneration in vivo .

catalog number base :

5580

product keywords :

Type-1 BMP bone morphogenetic protein receptors inhibitors inhibits ALK6 ALK2 ALK3 BMP and Other Activin Receptors 5580,

extended description :

Type I BMP receptor inhibitor

chemical name text :

4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

formula :

C 27 H 25 N 5 O 2

formula text :

C27H25N5O2

cas num :

1206711-14-9

2020 USD :

205

2021 USD :

212 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage