5580/10 | Tocris Bioscience 5580/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5580/10

catalog :

5580/10

quantity :

10 mg (also 50 mg)

price :

267 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Dalghi M, Ruiz W, Clayton D, Montalbetti N, Daugherty S, Beckel J, et al. Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception. JCI Insight. 2021;6: pubmed publisher
Stuart H, Stirparo G, Lohoff T, Bates L, Kinoshita M, Lim C, et al. Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell Stem Cell. 2019;25:388-406.e8 pubmed publisher

image

image 1 :

Cat.No. 5580 - DMH2 C27H25N5O2 CAS No. 1206711-14-9

product information

master code :

5580

SKU :

5580/10

product name :

DMH2

unit size :

10 mg (also 50 mg)

description :

Type I BMP receptor inhibitor

target :

BMP and Other Activin Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

451.52

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DMH2 is a type I BMP receptor inhibitor (Ki values are 1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits 30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro . Enhances liver regeneration in vivo .

top caption :

Type I BMP receptor inhibitor

extended description :

Type I BMP receptor inhibitor

chemical name text :

4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

formula :

C27H25N5O2

formula text :

C27H25N5O2

cas num :

1206711-14-9

USD :

267 USD

product details :

Type I BMP receptor inhibitor

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage