EPZ 004777 | Tocris Bioscience 5567 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

EPZ 004777

catalog :

5567

quantity :

10 mg

price :

279 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Ebrahimi A, Sevinç K, Gürhan Sevinç G, Cribbs A, Philpott M, Uyulur F, et al. Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming. Nat Chem Biol. 2019;15:519-528 pubmed publisher

product information

brand :

Tocris

master code :

5567

SKU :

5567/10

product name :

EPZ 004777

description :

Highly potent DOT1L inhibitor

target :

Lysine Methyltransferase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

539.67

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Highly potent DOT1L inhibitor (IC50 = 0.4 nM). Exhibits 1000-fold selectivity for DOT1L over a panel of other methyltransferases. Selectively inhibits proliferation and induces apoptosis of MLL -rearranged cells in vitro . Prolongs survival in a MLL xenograft mouse model. Enhances efficiency of Yamanaka-factor factor reprogramming of fibroblasts by 3-4-fold.

catalog number base :

5567

product keywords :

EPZ004777 highly potent DOT1L methyltransferases histones inhibitors inhibits HMTs MLL leukemia mll-rearranged H3K79me Lysine Methyltransferases Other Lysine Methyltransferases Stem Cell Reprogramming 5567,

extended description :

Highly potent DOT1L inhibitor

chemical name text :

7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]- -D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

formula :

C 28 H 41 N 7 O 4

formula text :

C28H41N7O4

cas num :

1338466-77-5

2020 USD :

270

2021 USD :

279 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage