5567/10 | Tocris Bioscience 5567/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5567/10

catalog :

5567/10

quantity :

10 mg

price :

350 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Ebrahimi A, Sevinç K, Gürhan Sevinç G, Cribbs A, Philpott M, Uyulur F, et al. Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming. Nat Chem Biol. 2019;15:519-528 pubmed publisher

image

image 1 :

Cat.No. 5567 - EPZ 004777 C28H41N7O4 CAS No. 1338466-77-5

product information

master code :

5567

SKU :

5567/10

product name :

EPZ 004777

unit size :

10 mg

description :

Highly potent DOT1L inhibitor

target :

Lysine Methyltransferase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

539.67

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

EPZ 004777 is a highly potent DOT1L inhibitor (IC50 = 0.4 nM). Exhibits 1000-fold selectivity for DOT1L over a panel of other methyltransferases. Selectively inhibits proliferation and induces apoptosis of MLL -rearranged cells in vitro . Prolongs survival in a MLL xenograft mouse model. Enhances efficiency of Yamanaka-factor factor reprogramming of fibroblasts by 3-4-fold. . For more information about how EPZ 004777 may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs

top caption :

Highly potent DOT1L inhibitor

extended description :

Highly potent DOT1L inhibitor

chemical name text :

7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]- -D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

formula :

C28H41N7O4

formula text :

C28H41N7O4

cas num :

1338466-77-5

USD :

350 USD

product details :

Highly potent DOT1L inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage