DREADD agonist 21 | Tocris Bioscience 5548 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

DREADD agonist 21

catalog :

5548

quantity :

10 mg (also 50 mg)

price :

203 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Smith K, Bucci D, Luikart B, Mahler S. DREADDS: Use and application in behavioral neuroscience. Behav Neurosci. 2016;130:137-55 pubmed publisher

product information

brand :

Tocris

master code :

5548

SKU :

5548/10

product name :

DREADD agonist 21

description :

Potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

target :

Buffers, Chelators and Reagents

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

278.35

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent muscarinic DREADD agonist (pEC50 values are 8.91, 8.48 and 7.77 for hM1Dq, hM3Dq and hM4Di in vitro , respectively). Exhibits 10-fold higher affinity for hM1Dq and hM4Di compared to wild type receptors. Also displays little to no activity at wild type M3 receptors. Activates neurons expressing hM3Dq DREADDS and inhibits activity in neurons expressing hM4Di in vivo . Displays excellent brain permeability. Water soluble salt also available, DREADD agonist 21 hydrochloride (Cat. No. 6422).

catalog number base :

5548

product keywords :

designer receptors drugs DREADDs hM3Dq muscarinic receptors compound 21 C21 Compound 21 C21 DREADDs Non-selective Muscarinics 5548, Chemogenetics

extended description :

Potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

chemical name text :

11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

formula :

C 17 H 18 N 4

formula text :

C17H18N4

cas num :

56296-18-5

2020 USD :

193

2021 USD :

203 USD

alt names :

Compound 21, C21

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage