5548/10 | Tocris Bioscience 5548/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5548/10

catalog :

5548/10

quantity :

10 mg (also 50 mg)

price :

264 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Liu S, Ifebi B, Johnson F, Xu A, Ho J, Yang Y, et al. The gut signals to AGRP-expressing cells of the pituitary to control glucose homeostasis. J Clin Invest. 2023;133: pubmed publisher
Ding W, Fischer L, Chen Q, Li Z, Yang L, You Z, et al. Highly synchronized cortical circuit dynamics mediate spontaneous pain in mice. J Clin Invest. 2023;133: pubmed publisher
Shrestha P, Shan Z, Mamcarz M, Ruiz K, Zerihoun A, Juan C, et al. Amygdala inhibitory neurons as loci for translation in emotional memories. Nature. 2020;586:407-411 pubmed publisher
Pati S, Saba K, Salvi S, Tiwari P, Chaudhari P, Verma V, et al. Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior. elife. 2020;9: pubmed publisher
Smith K, Bucci D, Luikart B, Mahler S. DREADDS: Use and application in behavioral neuroscience. Behav Neurosci. 2016;130:137-55 pubmed publisher

product information

master code :

5548

SKU :

5548/10

product name :

DREADD agonist 21

unit size :

10 mg (also 50 mg)

description :

Potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

target :

DREADD Activators

category :

Small Molecules

purity :

98%

observed molecular weight :

278.35

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DREADD agonist 21 is a potent muscarinic DREADD agonist (pEC50 values are 8.91, 8.48 and 7.77 for hM1Dq, hM3Dq and hM4Di in vitro , respectively). Exhibits 10-fold higher affinity for hM1Dq and hM4Di compared to wild type receptors. Also displays little to no activity at wild type M3 receptors. Activates neurons expressing hM3Dq DREADDS and inhibits activity in neurons expressing hM4Di in vivo . Displays excellent brain permeability. Water soluble salt also available, DREADD agonist 21 hydrochloride (Cat. No. 6422).

top caption :

Potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

extended description :

Potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

chemical name text :

11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

formula :

C17H18N4

formula text :

C17H18N4

cas num :

56296-18-5

USD :

264 USD

product details :

Potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

alt names :

Compound 21,C21

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage