5547/10 | Tocris Bioscience 5547/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5547/10

catalog :

5547/10

quantity :

10 mg (also 50 mg)

price :

224 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Sambri I, Ferniani M, Campostrini G, Testa M, Meraviglia V, de Araujo M, et al. RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome. Nat Commun. 2023;14:2775 pubmed publisher
Gómez N, Lu W, Lim J, Kiselyov K, Campagno K, Grishchuk Y, et al. Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation. FASEB J. 2017;: pubmed publisher

image

image 1 :

Cat.No. 5547 - MK6-83 C16H20N2O2S2 CAS No. 1062271-24-2

product information

master code :

5547

SKU :

5547/10

product name :

MK6-83

unit size :

10 mg (also 50 mg)

description :

TRPML channel activator

target :

TRPML Channel Activators

category :

Small Molecules

purity :

98%

observed molecular weight :

336.47

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MK6-83 is a TRPML channel activator (EC50 = 110 nM). Also activates F408 and F465L TRPML mutants (EC50 values are 0.1 and 1.23 M respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.

top caption :

TRPML channel activator

extended description :

TRPML channel activator

chemical name text :

5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide

formula :

C16H20N2O2S2

formula text :

C16H20N2O2S2

cas num :

1062271-24-2

USD :

224 USD

product details :

TRPML channel activator

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage