5545/10 | Tocris Bioscience 5545/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5545/10

catalog :

5545/10

quantity :

10 mg (also 50 mg)

price :

213 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Sophocleous R, Berg T, Finol Urdaneta R, Sluyter V, Keshiya S, Bell L, et al. Pharmacological and genetic characterisation of the canine P2X4 receptor. Br J Pharmacol. 2020;177:2812-2829 pubmed publisher
Datta G, Miller N, Afghah Z, Geiger J, Chen X. HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells. Front Cell Neurosci. 2019;13:329 pubmed publisher
Janks L, Sharma C, Egan T. A central role for P2X7 receptors in human microglia. J Neuroinflammation. 2018;15:325 pubmed publisher

image

image 1 :

Cat.No. 5545 - BX 430 C15H15Br2N3O CAS No. 688309-70-8

product information

master code :

5545

SKU :

5545/10

product name :

BX 430

unit size :

10 mg (also 50 mg)

description :

Selective P2X4 allosteric antagonist

target :

P2X Receptor Antagonists

category :

Small Molecules

purity :

99%

observed molecular weight :

413.11

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BX 430 is a selective P2X4 allosteric antagonist (IC50 = 0.54 M). Exhibits 10-fold selectivity for human P2X4 receptors over P2X1, P2X2, P2X3, P2X5 and P2X7 receptors. Binds noncompetitively at extracellular allosteric site. Effective at human and zebrafish, but not mouse and rat P2X4 receptors.

top caption :

Selective P2X4 allosteric antagonist

extended description :

Selective P2X4 allosteric antagonist

chemical name text :

N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N -(3-pyridinyl)urea

formula :

C15H15Br2N3O

formula text :

C15H15Br2N3O

cas num :

688309-70-8

USD :

213 USD

product details :

Selective P2X4 allosteric antagonist

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage