Echinomycin | Tocris Bioscience 5520 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Echinomycin

catalog :

5520

quantity :

1 mg

price :

118 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Kong D, Park E, Stephen A, Calvani M, Cardellina J, Monks A, et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005;65:9047-55 pubmed

product information

brand :

Tocris

master code :

5520

SKU :

5520/1

product name :

Echinomycin

description :

Highly potent and selective HIF-1 inhibitor

target :

HIF Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

1101.26

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Highly potent and selective HIF-1 inhibitor (IC50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF- B. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells. Eradicates mouse lymphomas and human AML xenografts by eliminating CSCs.

catalog number base :

5520

product keywords :

Highly potent selective HIF-1α inhibitors inhibits cancer stem cells VEGF lymphomas Quinomycin A Hypoxia Inducible Factors 5520, Hypoxia Inducible Factors, Hypoxia Inducible Factor

extended description :

Highly potent and selective HIF-1 inhibitor

chemical name text :

N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether

formula :

C 51 H 64 N 12 O 12 S 2

formula text :

C51H64N12O12S2

cas num :

512-64-1

2020 USD :

113

2021 USD :

118 USD

alt names :

Quinomycin A

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage