5520/1 | Tocris Bioscience 5520/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5520/1

catalog :

5520/1

quantity :

1 mg

price :

149 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Kullmann J, Trivedi N, Howell D, Laumonnerie C, Nguyen V, Banerjee S, et al. Oxygen Tension and the VHL-Hif1α Pathway Determine Onset of Neuronal Polarization and Cerebellar Germinal Zone Exit. Neuron. 2020;106:607-623.e5 pubmed publisher
Kong D, Park E, Stephen A, Calvani M, Cardellina J, Monks A, et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005;65:9047-55 pubmed

product information

master code :

5520

SKU :

5520/1

product name :

Echinomycin

unit size :

1 mg

description :

Highly potent and selective HIF-1 inhibitor

target :

HIF Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

1101.26

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Echinomycin is a highly potent and selective HIF-1 inhibitor (IC50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF- B. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells. Eradicates mouse lymphomas and human AML xenografts by eliminating CSCs.

top caption :

Highly potent and selective HIF-1 inhibitor

extended description :

Highly potent and selective HIF-1 inhibitor

chemical name text :

N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether

formula :

C51H64N12O12S2

formula text :

C51H64N12O12S2

cas num :

512-64-1

USD :

149 USD

product details :

Highly potent and selective HIF-1 inhibitor

alt names :

Quinomycin A

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage