product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
AMG PERK 44
catalog :
5517
quantity :
10 mg (also 50 mg)
price :
270 USD
more info or order :
citations: 3
Reference
Mahameed M, Wilhelm T, Darawshi O, Obiedat A, Tommy W, Chintha C, et al. The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors. Cell Death Dis. 2019;10:300 pubmed publisher
Roest G, Hesemans E, Welkenhuyzen K, Luyten T, Engedal N, Bultynck G, et al. The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca2+-Dependent Manner. Cells. 2018;7: pubmed publisher
Rojas Rivera D, Delvaeye T, Roelandt R, Nerinckx W, Augustyns K, Vandenabeele P, et al. When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157. Cell Death Differ. 2017;24:1100-1110 pubmed publisher
product information
brand :
Tocris
master code :
5517
SKU :
5517/10
product name :
AMG PERK 44
description :
Potent and selective PERK inhibitor; orally bioavailable
target :
PERK Inhibitors
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
561.07
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent and selective PERK inhibitor (IC50 = 6 nM). Exhibits 160-fold selectivity for PERK over B-Raf and GCN2, as well as a panel of 387 other kinases. Orally bioavailable.
catalog number base :
5517
product keywords :
AMGPERK44 PERK inhibitors inhibits potent selective protein kinase R-like PKR ER orally bioavailable PERK 5517,
extended description :
Potent and selective PERK inhibitor; orally bioavailable
chemical name text :
4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride
formula :
C 34 H 28 N 4 O 2 .HCl
formula text :
C34H28N4O2.HCl
cas num :
1883548-84-2
2020 USD :
262
2021 USD :
270 USD
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK