product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
5517/10
catalog :
5517/10
quantity :
10 mg (also 50 mg)
price :
345 USD
more info or order :
citations: 8
Reference
Bassot A, Chen J, Takahashi Yamashiro K, Yap M, Gibhardt C, Le G, et al. The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria. Cell Rep. 2023;42:111899 pubmed publisher
Helseth A, Hernández Martinez R, Hall V, Oliver M, Turner B, Caffall Z, et al. Cholinergic neurons constitutively engage the ISR for dopamine modulation and skill learning in mice. Science. 2021;372: pubmed publisher
Vallejo Gracia A, Chen I, Perrone R, Besnard E, Boehm D, Battivelli E, et al. FOXO1 promotes HIV latency by suppressing ER stress in T cells. Nat Microbiol. 2020;: pubmed publisher
Mohamed E, Sierra R, Trillo Tinoco J, Cao Y, Innamarato P, Payne K, et al. The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling. Immunity. 2020;52:668-682.e7 pubmed publisher
Kapoor A, Chen C, Iozzo R. Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells. J Biol Chem. 2020;295:6344-6356 pubmed publisher
Mahameed M, Wilhelm T, Darawshi O, Obiedat A, Tommy W, Chintha C, et al. The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors. Cell Death Dis. 2019;10:300 pubmed publisher
Roest G, Hesemans E, Welkenhuyzen K, Luyten T, Engedal N, Bultynck G, et al. The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2α and of LC3-II in a Ca2+-Dependent Manner. Cells. 2018;7: pubmed publisher
Rojas Rivera D, Delvaeye T, Roelandt R, Nerinckx W, Augustyns K, Vandenabeele P, et al. When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157. Cell Death Differ. 2017;24:1100-1110 pubmed publisher
product information
master code :
5517
SKU :
5517/10
product name :
AMG PERK 44
unit size :
10 mg (also 50 mg)
description :
Potent and selective PERK inhibitor; orally bioavailable
target :
PERK Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
561.07
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
AMG PERK 44 is a potent and selective PERK inhibitor (IC50 = 6 nM). Exhibits 160-fold selectivity for PERK over B-Raf and GCN2, as well as a panel of 387 other kinases. Orally bioavailable.
top caption :
Potent and selective PERK inhibitor; orally bioavailable
extended description :
Potent and selective PERK inhibitor; orally bioavailable
chemical name text :
4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride
formula :
C34H28N4O2.HCl
formula text :
C34H28N4O2.HCl
cas num :
1883548-84-2
USD :
345 USD
product details :
Potent and selective PERK inhibitor; orally bioavailable
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK