5512/10 | Tocris Bioscience 5512/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5512/10

catalog :

5512/10

quantity :

10 mg (also 50 mg)

price :

213 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Tharp K, Higuchi Sanabria R, Timblin G, Ford B, Garzon Coral C, Schneider C, et al. Adhesion-mediated mechanosignaling forces mitohormesis. Cell Metab. 2021;33:1322-1341.e13 pubmed publisher

image

image 1 :

Cat.No. 5512 - BIX NHE1 inhibitor C16H19F3N4O2.HCl CAS No. 1422252-46-7

product information

master code :

5512

SKU :

5512/10

product name :

BIX NHE1 inhibitor

unit size :

10 mg (also 50 mg)

description :

Potent and selective NHE1 inhibitor

target :

Na+/Ca2+ Exchanger Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

392.8

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BIX NHE1 inhibitor is a potent and selective NHE1 inhibitor (IC50 = 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo . Prevents phenylephrine -induced cardiomyocyte hypertrophy in vitro , and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable.

top caption :

Potent and selective NHE1 inhibitor

extended description :

Potent and selective NHE1 inhibitor

chemical name text :

4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamide hydrochloride

formula :

C16H19F3N4O2.HCl

formula text :

C16H19F3N4O2.HCl

cas num :

1422252-46-7

USD :

213 USD

product details :

Potent and selective NHE1 inhibitor

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage