R 547 | Tocris Bioscience 5494 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

R 547

catalog :

5494

quantity :

10 mg

price :

235 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5494

SKU :

5494/10

product name :

R 547

description :

Potent and selective cdk inhibitor; orally bioavailable

target :

Cyclin-dependent Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

441.45

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective CDK inhibitor (Ki values are 1, 2, 3, 46, 171 and 260 nM for CDK4/cyclin D1, CDK1/cyclin B, CDK2/cyclin E, GSK3 , CDK7/cyclin H and GSK3 ). Exhibits no effect against a panel of 120 other kinases (Ki 5,000 nM). Inhibits the proliferation of tumor cell lines independent of multidrug resistant status, or p53 status. Suppresses retinoblastoma protein in tumor cells and xenografts. Also inhibits tumor growth in the HCT116 human colorectal tumor xenograft model in nude mice. Orally bioavailable.

catalog number base :

5494

product keywords :

R547 Cyclin-dependent protein kinases inhibitors inhibits potent selective cdk Cdk1 cdk2 cdk3 cdk4 cyclin D1 cyclin B cyclin E orally bioavailable Cyclin-dependent Kinase 5494,

extended description :

Potent and selective cdk inhibitor; orally bioavailable

chemical name text :

[4-Amino-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-5-pyrimidinyl](2,3-difluoro-6-methoxyphenyl)methanone

formula :

C 18 H 21 F 2 N 5 O 4 S

formula text :

C18H21F2N5O4S

cas num :

741713-40-6

2020 USD :

235

2021 USD :

235 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage