5494/10 | Tocris Bioscience 5494/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5494/10

catalog :

5494/10

quantity :

10 mg

price :

263 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 5494 - R 547 C18H21F2N5O4S CAS No. 741713-40-6

product information

master code :

5494

SKU :

5494/10

product name :

R 547

unit size :

10 mg

description :

Potent and selective cdk inhibitor; orally bioavailable

target :

Cyclin-dependent Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

441.45

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

R 547 is a potent and selective CDK inhibitor (Ki values are 1, 2, 3, 46, 171 and 260 nM for CDK4/cyclin D1, CDK1/cyclin B, CDK2/cyclin E, GSK3 , CDK7/cyclin H and GSK3 ). Exhibits no effect against a panel of 120 other kinases (Ki 5,000 nM). Inhibits the proliferation of tumor cell lines independent of multidrug resistant status, or p53 status. Suppresses retinoblastoma protein in tumor cells and xenografts. Also inhibits tumor growth in the HCT116 human colorectal tumor xenograft model in nude mice. Orally bioavailable.

top caption :

Potent and selective cdk inhibitor; orally bioavailable

extended description :

Potent and selective cdk inhibitor; orally bioavailable

chemical name text :

[4-Amino-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-5-pyrimidinyl](2,3-difluoro-6-methoxyphenyl)methanone

formula :

C18H21F2N5O4S

formula text :

C18H21F2N5O4S

cas num :

741713-40-6

USD :

263 USD

product details :

Potent and selective cdk inhibitor; orally bioavailable

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage