5493/10 | Tocris Bioscience 5493/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5493/10

catalog :

5493/10

quantity :

10 mg (also 50 mg)

price :

286 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Warren N, Eastman A. Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe. J Biol Chem. 2019;294:1763-1778 pubmed publisher

image

image 1 :

Cat.No. 5493 - XL 413 hydrochloride C14H12ClN3O2.HCl CAS No. 1169562-71-3

product information

master code :

5493

SKU :

5493/10

product name :

XL 413 hydrochloride

unit size :

10 mg (also 50 mg)

description :

Potent and selective Cdc7 inhibitor

target :

Other Kinase Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

326.18

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

XL 413 hydrochloride is a potent and selective Cdc7 inhibitor (IC50 = 3.4 nM). Exhibits 12-fold selectivity for Cdc7 over PIM-1 kinase and 30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice. XL 413 also improves homology-directed repair (HDR) editing in hematopoietic stem cells (HSC).

top caption :

Potent and selective Cdc7 inhibitor

extended description :

Potent and selective Cdc7 inhibitor

chemical name text :

8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride

formula :

C14H12ClN3O2.HCl

formula text :

C14H12ClN3O2.HCl

cas num :

1169562-71-3

USD :

286 USD

product details :

Potent and selective Cdc7 inhibitor

alt names :

BMS 863233

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage