KRIBB11 | Tocris Bioscience 5480 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

KRIBB11

catalog :

5480

quantity :

50 mg

price :

464 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Yoon Y, Kim J, Shin K, Shin D, Han Y, Lee Y, et al. KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J Biol Chem. 2011;286:1737-47 pubmed publisher

product information

brand :

Tocris

master code :

5480

SKU :

5480/50

product name :

KRIBB11

description :

HSF1 inhibitor

target :

HSP90 Inhibitors

category :

Small Molecules

unit size :

50 mg

main entrez gene id :

3320

purity :

99%

observed molecular weight :

284.27

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Heat shock factor (HSF) inhibitor (IC50 = 1.2 M). Increases apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin (Cat. No. 1368) and 17-AAG (Cat. No. 1515). Blocks downstream induction of HSP27 and HSP70. Inhibits tumor growth in vivo .

catalog number base :

5480

product keywords :

HSF1 inhibitors inhibits heat shock factors 1 HSP90 HSP70 HSP27 proteins Hsp90 Hsp70 Other Transcription Factors 5480,

extended description :

HSF1 inhibitor

chemical name text :

N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine

formula :

C 13 H 12 N 6 O 2

formula text :

C13H12N6O2

cas num :

342639-96-7

2020 USD :

454

2021 USD :

464 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage