CRID3 sodium salt | Tocris Bioscience 5479 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CRID3 sodium salt

catalog :

5479

quantity :

10 mg (also 50 mg)

price :

201 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Goddard P, Sanchez Garrido J, Slater S, Kalyan M, Ruano Gallego D, Marches O, et al. Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages. Cell Rep. 2019;27:1008-1017.e6 pubmed publisher
Chauhan D, Bartok E, Gaidt M, Bock F, Herrmann J, Seeger J, et al. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages. Cell Rep. 2018;25:2354-2368.e5 pubmed publisher

product information

brand :

Tocris

master code :

5479

SKU :

5479/10

product name :

CRID3 sodium salt

description :

Potent NLRP3 inflammasome inhibitor; inhibits IL-1 production

target :

Inflammasomes Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

426.46

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent NLRP3 inflammasome inhibitor; closes the active conformation of NLRP3 to the inactive state. Directly interacts with the Walker B motif within the NLRP3 NACHT domain. Inhibits IL-1 , IL-18 and IL-1 production (IC50 values are 7.2, 10.3 and 12-18 nM, respectively). Selective for NLRP3 over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S -transferase omega 1 inhibitor. Orally bioavailable.

catalog number base :

5479

product keywords :

CP456773 cytokine release inhibitory drug CRID3 Glutathione S-transferase omega 1 GSTO1 inhibitors inhibits MCC950 nod-like receptors NLRP3 inflammasome CP-456773 MCC 950 Other Transferases Cytokines Inflammasomes 5479,

extended description :

Potent NLRP3 inflammasome inhibitor; inhibits IL-1 production

chemical name text :

N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt

formula :

C 20 H 23 N 2 NaO 5 S

formula text :

C20H23N2NaO5S

cas num :

256373-96-3

2020 USD :

197

2021 USD :

201 USD

alt names :

CP-456773, MCC 950

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage