5479/10 | Tocris Bioscience 5479/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5479/10

catalog :

5479/10

quantity :

10 mg (also 50 mg)

price :

265 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
The E, de Graaf D, Zhai Y, Yao Q, Ao L, Fullerton D, et al. Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3. Proc Natl Acad Sci U S A. 2022;119:e2202577119 pubmed publisher
Szab xf3 D, Tod P, G xf6 l xf6 ncs xe9 r F, Rom xe1 n V, Lendvai B, Otrokocsi L, et al. Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway. Brain Behav Immun. 2022;101:318-332 pubmed publisher
Hernandez Cuellar E, Guerrero Barrera A, Avelar Gonzalez F, D xed az J, Ch xe1 vez Reyes J, Salazar de Santiago A. An in vitro study of ApxI from Actinobacillus pleuropneumoniae serotype 10 and induction of NLRP3 inflammasome-dependent cell death. Vet Rec Open. 2021;8:e20 pubmed publisher
Huang C, Zhang C, Yang P, Chao R, Yue Z, Li C, et al. Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway. Drug Des Devel Ther. 2020;14:4901-4913 pubmed publisher
Nizami S, Arunasalam K, Green J, Cook J, Lawrence C, Zarganes Tzitzikas T, et al. Inhibition of the NLRP3 inflammasome by HSP90 inhibitors. Immunology. 2021;162:84-91 pubmed publisher
Linder A, Bauernfried S, Cheng Y, Albanese M, Jung C, Keppler O, et al. CARD8 inflammasome activation triggers pyroptosis in human T cells. EMBO J. 2020;39:e105071 pubmed publisher
Subbarao S, Sanchez Garrido J, Krishnan N, Shenoy A, Robertson B. Genetic and pharmacological inhibition of inflammasomes reduces the survival of Mycobacterium tuberculosis strains in macrophages. Sci Rep. 2020;10:3709 pubmed publisher
Atluri V, Tiwari S, Rodriguez M, Kaushik A, Yndart A, Kolishetti N, et al. Inhibition of Amyloid-Beta Production, Associated Neuroinflammation, and Histone Deacetylase 2-Mediated Epigenetic Modifications Prevent Neuropathology in Alzheimer's Disease in vitro Model. Front Aging Neurosci. 2019;11:342 pubmed publisher
Goddard P, Sanchez Garrido J, Slater S, Kalyan M, Ruano Gallego D, Marches O, et al. Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages. Cell Rep. 2019;27:1008-1017.e6 pubmed publisher
Chauhan D, Bartok E, Gaidt M, Bock F, Herrmann J, Seeger J, et al. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages. Cell Rep. 2018;25:2354-2368.e5 pubmed publisher

product information

master code :

5479

SKU :

5479/10

product name :

CRID3 sodium salt

unit size :

10 mg (also 50 mg)

description :

Potent NLRP3 inflammasome inhibitor; inhibits IL-1 production

target :

Inflammasomes Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

426.46

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CRID3 sodium salt is a potent NLRP3 inflammasome inhibitor; closes the active conformation of NLRP3 to the inactive state. Directly interacts with the Walker B motif within the NLRP3 NACHT domain. Inhibits IL-1 , IL-18 and IL-1 production (IC50 values are 7.2, 10.3 and 12-18 nM, respectively). Selective for NLRP3 over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S -transferase omega 1 inhibitor. Orally bioavailable.

top caption :

Potent NLRP3 inflammasome inhibitor; inhibits IL-1 production

extended description :

Potent NLRP3 inflammasome inhibitor; inhibits IL-1 production

chemical name text :

N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt

formula :

C20H23N2NaO5S

formula text :

C20H23N2NaO5S

cas num :

256373-96-3

USD :

265 USD

product details :

Potent NLRP3 inflammasome inhibitor; inhibits IL-1 production

alt names :

CP-456773,MCC 950

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage