5473/1 | Tocris Bioscience 5473/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5473/1

catalog :

5473/1

quantity :

1 mg

price :

324 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Llori xe1 n Salvador M, Byrne E, Szczepan M, Little K, Chen M, Xu H. Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells. J Neuroinflammation. 2022;19:182 pubmed publisher
Sharma R, George A, Nimmagadda M, Ortolan D, Karla B, Qureshy Z, et al. Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model. Nat Commun. 2021;12:7293 pubmed publisher
Emmons T, Giridharan T, Singel K, Khan A, Ricciuti J, Howard K, et al. Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer. Cancer Immunol Res. 2021;9:790-810 pubmed publisher
Ma Y, Zabell T, Creasy A, Yang X, Chatterjee V, Villalba N, et al. Gut Ischemia Reperfusion Injury Induces Lung Inflammation via Mesenteric Lymph-Mediated Neutrophil Activation. Front Immunol. 2020;11:586685 pubmed publisher
Liu H, Kim H, Deepak R, Wang L, Chung K, Fan H, et al. Orthosteric and allosteric action of the C5a receptor antagonists. Nat Struct Mol Biol. 2018;25:472-481 pubmed publisher
Wang Y, Lai P, Chen X, He C, Huang X, Geng S, et al. Attenuation of cGVHD by C5a/C5aR blockade is associated with increased frequency of Treg. Sci Rep. 2017;7:3603 pubmed publisher

product information

master code :

5473

SKU :

5473/1

product name :

PMX 53

unit size :

1 mg

description :

Potent C5a receptor antagonist

target :

Complement Signaling inhibitors

category :

Peptides

purity :

95%

observed molecular weight :

896.1

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

PMX 53 is a potent C5a receptor antagonist (IC50 = 20 nM). Also MrgX2 agonist. Stimulates MrgX2-mediated mast cell degranulation. Also inhibits C5a-induced hypernociception in rats, inhibits lung metastasis in a mouse breast cancer model and reduces atherosclerotic lesions in a mouse model of atherosclerosis. . Negative Control also available.

top caption :

Potent C5a receptor antagonist

extended description :

Potent C5a receptor antagonist

formula :

C47H65N11O7

formula text :

C47H65N11O7

cas num :

219639-75-5

USD :

324 USD

product details :

Potent C5a receptor antagonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage