5456/10 | Tocris Bioscience 5456/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5456/10

catalog :

5456/10

quantity :

10 mg (also 50 mg)

price :

261 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Barghout S, Mann M, Aman A, Yu Y, Alteen M, Schimmer A, et al. Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes. ACS Chem Biol. 2022;17:2801-2816 pubmed publisher
Barghout S, Aman A, Nouri K, Blatman Z, Arevalo K, Thomas G, et al. A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity. JCI Insight. 2021;: pubmed publisher
Abbassi R, Recasens A, Indurthi D, Johns T, Stringer B, Day B, et al. Lower Tubulin Expression in Glioblastoma Stem Cells Attenuates Efficacy of Microtubule-Targeting Agents. ACS Pharmacol Transl Sci. 2019;2:402-413 pubmed publisher

image

image 1 :

Cat.No. 5456 - Zosuquidar trihydrochloride C32H31F2N3O2.3HCl CAS No. 167465-36-3

product information

master code :

5456

SKU :

5456/10

product name :

Zosuquidar trihydrochloride

unit size :

10 mg (also 50 mg)

description :

High affinity P-gp inhibitor

target :

Multidrug Transporter Inhibitors

category :

Small Molecules

purity :

97%

observed molecular weight :

636.99

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Zosuquidar trihydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.

top caption :

High affinity P-gp inhibitor

extended description :

High affinity P-gp inhibitor

chemical name text :

( R)-4-[(1a ,6 ,10b )-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]- -[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride

formula :

C32H31F2N3O2.3HCl

formula text :

C32H31F2N3O2.3HCl

cas num :

167465-36-3

USD :

261 USD

product details :

High affinity P-gp inhibitor

alt names :

LY 335979

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage